Titan 500 Injection, is a third-generation cephalosporin antibiotic with broad-spectrum antibacterial activity. This medicine is used to treat infections caused by gram-positive and gram-negative bacteria. This article provides information on Titan 500 Injection’s uses, composition, dosage, side effects, contraindications, precautions and other important information. Read the full article to know more.

Table of Contents

Composition and form

The active ingredient in Titan 500 Injection is cefotaxime sodium, which is a powerful antibiotic and inhibits the growth of bacteria. This injection is available in 500 mg strength, in addition to 250, 1000, 2000 mg strength. Most often it is given by IV (intravenous) or IM (intramuscular).

Method of action

Cefotaxime sodium inhibits bacterial cell wall synthesis, resulting in bacterial death. It is effective against most gram-negative bacteria, but is also beneficial for some gram-positive bacteria.

Uses and Indications for Titan 500 Injection

Injection Below is complete information about the conditions under which Titan 500 Injection is used.

Respiratory tract infections

Respiratory tract infections are caused by bacteria that infect the lungs and bronchial tubes. Titan 500 is helpful in treating these infections Pneumonia and Bronchitis.

Pneumonia: Pneumonia is a serious respiratory infection in which the small air sacs (alveoli) become filled with pus or fluid. Titan 500 works against Streptococcus pneumoniae, Haemophilus influenzae and Klebsiella pneumoniae, which are the main causes of this disease.

Bronchitis: Titan 500 treats inflammation and infection by killing bacteria in cases of acute and chronic bronchitis.

Urinary Tract Infections (UTIs)

Urinary tract infections are mostly caused by Gram-negative bacteria such as Escherichia coli.

Pyelonephritis: It is an acute kidney infection that develops from untreated urinary tract infections. Titan 500 protects kidney tissue from damage by targeting bacteria.

Cystitis: It is a bladder infection characterized by burning sensation while urinating and frequent urination. Titan 500 helps remove bacteria from the lining of the bladder.

Skin and Soft Tissue Infections (SSTIs)

Skin and soft tissue infections are caused by bacterial overgrowth.

Cellulitis: It is a bacterial infection of the tissue under the skin, such as Staphylococcus aureus and Streptococcus pyogenes. Titan 500 eliminates inflammation and pain.

Abscesses: An abscesses is an infection that collects pus in a specific area. Titan 500 injection kills bacteria and prevents its spread.

Bone and Joint Infections

Titan 500 injection is used to treat bone and joint infections, such as osteomyelitis.

Osteomyelitis: It is a serious bacterial infection of the bone, mostly caused by Staphylococcus aureus. Titan 500 injection penetrates the infected bone and destroys the bacteria.

Sepsis and Septicemia

Sepsis is a life-threatening condition caused by the spread of a bacterial infection in the blood.

Life-Threatening Infections: Titan 500 injection is an effective treatment for bacteremia (bacteria in the blood), as it reduces the risk of organ failure in the body by inhibiting the growth of bacteria.

Abdominal Infections

Titan 500 injection helps treat severe and painful stomach infections.

Peritonitis: It occurs in the lining of the abdomen, often due to untreated appendicitis or injury. Titan 500 injection prevents the spread of infection by killing bacteria.

Typhoid and Paratyphoid Fevers

These fevers are caused by Salmonella typhi and Salmonella paratyphi.

Drug-Resistant Cases: When common antibiotics are not effective, Titan 500 injection is used to treat resistant cases.

Post-Operative Surgical Infections Infections

These infection are commonly occur after surgery, and Titan 500 injection is used to treat and prevent them.

Prevention and treatment: Titan 500 injection is given before and after surgery to prevent bacterial invasion and reduce the risk of surgical site infection.

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Dosage and method of use

Dosage

The dose and usage of Titan 500 Injection depends on the patient’s medical condition, severity of infection and age. It can also cause side effects if not taken in the correct dosage. Only a doctor can tell you the correct way to use it, but the usual dose is given below.

For Adults: 1-2 grams is given every 6-8 hours through a vein (Intravenous – IV) or muscle (Intramuscular – IM). The maximum recommended dose in adults is 12 grams a day, given in severe cases.

For Children: Children are given 50-200 mg/kg body weight, daily in several divided doses. For example, if a child weight 20 kg and the recommended daily dose is 100 mg/kg body weight, he would be given 2000 mg throughout the day (in 4 divided doses, each dose of 500 mg will be).

Missed Dosage

If you miss a dose of Titan 500 Injection, take it as soon as you remember. But if the next dose is near, skip the old dose and follow the usual schedule. Do not try to take a double dose, as this may increase the risk of side effects.

Be sure to consult your doctor if you miss a dose frequently. Make a schedule to remember the time of feeding and follow it strictly. If you are in the hospital, check with the medical staff that the dose is being given on time.

Overdose

It can cause harmful effects if taken in excess. In case of overdose, contact a doctor or hospital immediately and do not self-medicate. Overdose is treated in the hospital with symptomatic treatment and, if necessary, hemodialysis.

Method of Use

Intravenous – IV Method of Use

The IV method is preferred when treating severe infections or when immediate effects are needed. The powder form is reconstituted with sterile water or saline solution. 10 ml of sterile water is used to dissolve 500 mg of the dose.

The prepared solution is slowly injected into the patient’s veins over 20-30 minutes. This method is used to prevent possible side effects, such as vein irritation or thrombophlebitis.

Intramuscular – IM Method of Use

When IV access is not available, the IM method is used. For IM injection, cefotaxime powder is mixed with lidocaine solution.

2 mL of 1% lidocaine solution is used for a 500 mg dose. Lidocaine solution reduces pain and discomfort, which usually occurs with IM injections.

Injections are made into large muscle groups, such as the gluteus or deltoid muscles. The injection must be done deeply so as not to irritate the tissues beneath the skin.

Precautions and Warnings

Whenever you use a drug, it is important to first understand its precautions and warnings. If this is not done, the same medicine can harm you.

Allergic Reactions

Titan 500 Injection contains cefotaxime, which belongs to the cephalosporin group. If you are allergic to antibiotics of this group, you should not use this injection. Otherwise it may harm you.

Kidney and Liver Monitoring

Titan 500 Injection is metabolized and excreted by the kidneys and liver, so their function must be closely monitored. If this is not done, it can cause side effects.

Drug Interactions

There are certain medications that may be harmful to use with Titan 500 Injection. These include:

Aminoglycosides such as gentamicin
Anticoagulants such as warfarin
Probenecid

Use during pregnancy Titan 500 Injection

Titan 500 Injection should be used during pregnancy only if the potential benefit outweighs the potential harm. Animal studies have shown no harm during pregnancy, but safety has not been fully established due to limited human research. Pregnant women should use this medicine under the strict supervision of a doctor.

Use during breastfeeding Titan 500 Injection

Titan 500 Injection is recommended for breastfeeding mothers only when necessary. This medicine can pass to the baby through breast milk, which can cause the baby to have diarrhea, mouth infections (oral thrush), or bowel problems. So do not use it without doctor’s advice.

Other General Precautions

Long-term use: Long-term use of Titan 500 injection may increase the risk of developing drug-resistant bacteria.

Superinfections: Because it is a broad-spectrum antibiotic, prolonged use may increase the risk of Clostridium difficile-associated diarrhea (CDAD) and fungal infections.

Driving and using machinery: Dizziness or confusion may occur after injection, so avoid driving or operating heavy machinery.

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Side Effects

Titan 500 Injection is generally considered safe, but it can cause side effects when taken in high doses. Always remember that if you experience any side effects, inform your doctor immediately.

Mild Side Effects

These side effects are common and often short-lived. In most cases, they resolve on their own without any specific treatment.

Nausea: Some patients may experience nausea after receiving the injection, which is due to the drug’s gastrointestinal effects.

Vomiting: In some cases, nausea may be accompanied by vomiting, but this is rare

Diarrhea: Broad-spectrum antibiotics can affect the intestinal tract, causing loose stools or diarrhea.

Rash: Rash or mild allergic symptoms may appear on the skin, which is often due to an allergic reaction.

Severe Side Effects

Serious side effects are rare but can be potentially dangerous, so it is important to notice and treat them promptly.

Anaphylactic Reactions: This is a dangerous allergic reaction that can occur immediately after the injection. Symptoms include difficulty breathing, facial swelling, low blood pressure, and fainting.

Neutropenia: The lack of white blood cells makes the body more susceptible to infections. This may be due to prolonged use or high dosage.

Renal Dysfunction: Can have an adverse effect on kidney function, mostly in patients with pre-existing kidney problems. Symptoms include decreased urine output and swelling.

Titan 500 Injection Price in Pakistan

Talking about the price of Titan 500 injection in Pakistan, this price keeps increasing. Earlier it was priced at Rs 254.71, and now it has increased to Rs 275.39. I will do my best to let you know whenever there is a price change in the future.

Storage

Titan 500 Injection at room temperature (25°C). Use the reconstituted solution immediately or store it in the refrigerator for 24 hours۔

Titan 500mg Injection Information

Frequently Asked Questions about Titan 500mg Injection

Q1: What is Titan 500mg used for?

A1: Titan 500mg is used for various medical conditions. like Respiratory Tract Infections, Urinary Tract Infections (UTIs), Skin and Soft Tissue Infections (SSTIs), Bone and Joint Infections, Sepsis and Septicemia, Abdominal Infections, Typhoid and Paratyphoid Fevers, Post-Operative Surgical Infections Injection is used.

Q2: What is the drug Titan?

A2: Titan is a dangerous super-steroid drug developed by Doctor Young using Bane’s Venom as a chemical base along with elements from Poison Ivy’s plants.

Q3: What is the most common side effect of ceftriaxone?

A3: The most common side effects of Titan 500mg Injection are nausea, vomiting, diarrhea, and mild skin rash. In rare cases, severe side effects like anaphylaxis, neutropenia, or renal dysfunction may occur. Always consult your doctor if you experience any side effects.

Q4: Can a pregnant woman take ceftriaxone injection?

A4: Titan 500 Injection should be used during pregnancy only if the potential benefit outweighs the potential harm. Animal studies have shown no harm during pregnancy, but human safety has not been fully established. Consult your doctor before use.

Q5: Is ceftriaxone injection safe for breastfeeding mothers?

A5: Titan 500 Injection is recommended for breastfeeding mothers only when necessary. It can pass to the baby through breast milk, potentially causing diarrhea, mouth infections (oral thrush), or bowel problems in the infant. Always consult a doctor before using it.

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